British Neuroscience Association
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Plenary Lecturers

Graham Collingridge (Bristol) Insights into the molecular basis of memory
Salvador Moncada (London) Nitric oxide, bioenergetics and cell signaling
John Lowry (Conway, Ireland) In Vivo Voltammetry: Real-Time Monitoring of Brain Chemistry
Edvard Moser (Oslo) Entorhinal grid cells and hippocampal memory
Yves Barde (Switzerland) Neurotrophins in development and diseases
Helen Mayberg (Atlanta) Paths To Recovery: Modulating Putative Depression Circuits using Deep Brain Stimulation
Joe LeDoux (New York) Rembrance of Emotions Past: A View Through Fear


Symposia

The Neuropathology of Autism: recent advances in understanding neurochemical mechanisms.
Chair
Gene Blatt
Speakers
Gene Blatt (Boston) Neurochemical Alterations in the Cerebellar and Limbic Systems in Autism
Jane Yip (Boston) Functional status of cerebellar Purkinje cells in autism
Elaine Perry (Newcastle) Cholinergic systems in autism
Phil Luthert (Oxford) Neuroanatomcal substrates of autism
Payam Rezaie (Open University, Milton Keynes) Glial cells within the cerebral cortex in autism

Ubiquitination Dependent Regulation of Synaptic Development and Plasticity.
Chair Josef Kittler.
Speakers: Michael Ehlers (Durham) Bidirectional Control of Glutmatergic Synapses by Postsynaptic Ubiquitination
Andrea Brand (Cambridge) Control of synaptic development by the Anaphase Promoting Complex/Cyclosome
Scott Wilson (Alabama) Regulation of synaptic function by ubiquitin-specific protease 14
Jeremy Henley (MRC, Bristol): SUMOylation Regulates Kainate Receptor Mediated Synaptic Transmission

Neuroreparative approaches using stem cell biology.
Chair Stefan Przyborski
Speakers:
Maeve Caldwell (Cambridge) Neural stem cell therapy for Parkinsons Disease
Sue Barnett (Glasgow) Are there stem cells in the olfactory system
Anne Rosser (Cardiff): Finding cells for replacement therapy in Huntington's disease
Siddarthan Chandran (Cambridge) Embryonic solutions for adult problems

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A role for inflammation in neurodegeneration: Where do we stand? *
Chair Tom Connor
Speakers:
Thomas Connor (Dublin) Noradrenergic control of inflammatory processes in the CNS
Marina Lynch (Dublin) Neuronal-glial interactions, inflammation and synaptic function
Daniel Anthony (Oxford) The systemic control of acute and chronic inflammation in the brain
Robin Franklin (Cambridge) Inflammation and CNS remyelination

Cannabinoids: fate, food and fear. *
Chair Veronica Campbell
Speakers:
Veronica Campbell (Dublin) The influence of cannabinoids on neural fate.
Tim Kirkham (Liverpool) Cannabinoids, appetite and obesity
David Finn (Galway) Endocannabinoid-mediated modulation of fear-related behaviour: sites and mechanisms of action
Ruth Ross (Aberdeen) Cannabinoid Neuropharmacology: recent developments

Purines in physiology, plasticity and pathology.
Chair Bruno Frenguelli
Speakers:
Phil Haydon (Pennsylvania) Astrocytic purinergic signaling coordinates synaptic networks
Nick Dale (Warwick) Mechanisms of adenosine release in the basal forebrain and the control of sleep
Alex Gourine (UCL) The role of ATP in the brain mechanisms controlling breathing
Detlev Boison (Portland) Adenosine, astrogliosis and epilepsy: a rational approach for novel cell and gene therapies

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Circadian Rhythms in the Brain.
Chair Ela Pyza and Hugh Piggins.
Speakers:
Hugh Piggins (Manchester) Behavioural Feedback and Circadian Rhythms
Jolanta Zawilska (Poland) Melatonin in the avian retina and pineal gland - photic, circadian and neurochemical regulations
Michael Nitabach (USA) Membranes, Ions and Clocks: Cellular Physiology of Pacemaker Neurons
Ela Pyza Circadian plasticity of neurons and glial cells

Sleep and Anaesthesia: common mechanisms?
Chair Bill Wisden
Speakers:
Nick Franks (London) General anaesthesia and sleep pathways
Helmut Haas (Germany) Gabaergic inhibition of wake-active neurons

Synaptic Origami: protein folding at the synapse
Chair Vincent O Connor and Andreas Wyttenbach
Speakers:
Ulrich Hartl (Munich) Molecular Chaperone as modulators of proteotoxicity in neurodegenerative disease
Paul Skehel (Edinburgh) VAP proteins and neurodegeneration
Konrad Zinsmaier (Arizona) Synaptic function of the Synaptic Vesicle-associated CSP/Hsc70 Chaperone#
Giovanna Mallucci (London) Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.

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Emotion and Cognition: anatomical substrates and therapeutic targets.
Chair Colin Ingram
Speakers:
John Cryan (Cork) Novel Therapeutic targets for stress-related disoorders
Hugh Garavan (Dublin) Neuroanotomical substrates and disorders of frontal-lobe related cognitive processes

Subcellular and proteomic approaches to dissect neuronal signalling pathways
Chair Ralf Schoepfer
Speakers:
Jan Van Minnen (Netherlands) Cellular and proteomics approaches to protein synthesis in axons
Seth Grant (Cambridge) Evolution and diversity of the synapse proteome
Ralf Schoepfer (UCL) Posttranslational modifications and signaling in postsynaptic densities

From cell-cell recognition to memory formation
Chair Mike Stewart
Speakers:
Elisabeth Bock (Denmark) Structural biology of neuronal cells adhesion molecules and their counter receptors
Michael Stewart (Milton Keynes) The role of cell adhesion molecules (CAMs) and CAM mimetics in synaptic plasticity: ultrastructural studies.
Carmen Sandi (Switzerland) Role of cell adhesion molecules in memory consolidation and cognitive flexibility

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Alcohol: molecular and cellular mechanisms of intoxication, tolerance and addiction
Chair Lindy Holden-Dye
Speakers:
Dai Stephens (Sussex) Measuring motivation for moonshine in mutant mice; altered responses to booze and drugs in mice with mutations of GABAA receptor alpha subunits
Hilary Little (London) Alcohol, stress and memory
Rachel French (California) Drosophila as a genetic model for ethanol-induced neurodegeneration

Multi-sensory Processes *
Chair Fiona Newell
Speakers:
Fiona Newell (Dublin) Synaesthesia: a window into the genetic basis of multisensory processing
John Foxe (Dublin) How fast is multisensory integration in human cortex?
Stuart Smith (Dublin) A Multisensory spin on self-motion perception
Gemma Calvert (Bath) A combined intracranial EEG, MEG and fMRI look at audiovisual speech integration.

Alzheimer's Disease: current therapies and progress on the development of drugs to slow disease progression
Chair Mike O Neill and Eric Karran
Speakers:
Richard Mohs (Indianapolis) Alzheimer's Disease is a Worldwide Problem: The Burden and Current Standards of Care
Menelas Pangalos (New Jersey) An over-view of Beta-amyloid approaches
Peter Davis (New York) What is the significance of tau pathology in Alzheimer's disease?
Rachael Scahill (UCL) The Use of MRI for Tracking Disease Progression and Assessment of Novel Therapies in Alzheimer's Disease

Discovering drug effects through functional brain imaging
Chair Ingo Schiessl
Speakers:
Michael James (Essex) TBC
Steve Williams (Manchester) Probing Serotonin and Glutamate Actions on the Brain in vivo: Pharmacological Challenge fMRI in animal models and human volunteers
Nicola Sibson (Oxford) Modulating neuronal and haemodynamic responses: coupling and uncoupling
Ingo Schiessl (Manchester) Analysis of pMRI data with Blind Source Seperation

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Hippocampal neurogenesis in mood disorders and their treatment.
Sponsored by British Association for Psychopharmacology
Chair Clare Stanford and Kevin Fone
Speakers:
Erica Glasper (Yale) Neurogenesis: the key to depression and its treatment?
Eberhard Fuchs (Gottingen) Adult neurogenesis is susceptible to chronic stress
Jaime McCutcheon (UCL) Genetic background influences neurogenesis and other associated phenotypes in the NK1-/- mouse
Ian Reid (Aberdeen) Brain Plasticity and anytidepressant treatments: new cells, new connections

Basal Ganglia subcortical connections: exploring the brainstem.
Chair Paul Bolam and Philip Winn
Speakers
Philip Winn (St Andrews) Behavioural roles of the PPtg
Juan Mena-Segovia (Oxford) Physiological analyses of cholinergic and non-cholinergic neurons in the PPN that innervate the basal ganglia
Dipankar Nandi (Oxford) The role of the pedunculopontine nucleus in Parkinson’s disease
Peter Redgrave (Sheffield) Subcortical loops and through the basal ganglia

Thalamocortical development
Chair Zoltan Molnar
Speakers:
Nobuhiko Yamamoto (Japan) Activity Independent and Dependent Mechanisms for the Formation of the Thalamocortical Projection
Kevin Mitchell (Dublin) Specificity and plasticity in thalamocortical connectivity: lessons from Semaphorin-6A mutant mice
Guillermina Lopez-Bendito (Spain) Tangential Neuronal Migration Controls Axon Guidance: A Role for Neuregulin-1 in Thalamocortical Axon Navigation
David Price (Edinburgh) Molecular regulation of thalamocortical axonal navigation

New mutant models for neurodevelopmental and neurodegenerative disorders *
Chair John Waddington
Speakers
Dairin Kieran ( RCS) SOD1mt-PUMA double mutants in relation to amytrophic lateral sclerosis
Kevin Mitchell (Dublin) Semaphorin and Plexin mutants as models for disorders of connectivity
Elizabeth Fisher (London) An aneuploid mouse with a human chromosome modelling Down Syndrome
Colm O'Tuathaigh (RCS) Dissecting the genetic contribution to psychosis: new evidence from susceptibility gene mutants


* Coordinated by Neuroscience Ireland


For further information: bna2007@bna.org.uk, tel: 0151 794 4943/5449

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