PhD: The role of SV2A proteins and ligands in neuronal network activity
Closing date: 11 May 2012
Salary: £13,590 p.a.
Address: School of Pharmacy, University of Reading
Duration: 3 years
This fully-funded 3-year studentship will use electrophysiological and biochemical techniques to investigate the role of an important brain protein, synaptic vesicle protein 2A (SV2A), in neuronal activity. Agents that bind to SV2A are important anti-epileptic drugs, such as the class-leading drug, levetiracetam. The successful student will receive training in electrophysiological (multi-electrode array, patch clamp recording and signal processing) and cellular neuroscience techniques (including tissue culture, cell transfection, siRNA use and immunohistochemistry). The student will also have the opportunity to undertake research placements with UCB (Belgium) and attend national and international conferences to present results. The project forms part of an ongoing research theme within the supervisors’ research groups into the role of SV2A ligands effects in the CNS and associated pathophysiological hyperexcitability states.
EU and UK candidates holding or expecting 1st class, 2(i) or equivalent degrees in appropriate subject areas are invited to apply for these studentships that are available after Oct 2012 in the Faculty of Life Sciences which consists of five schools conducting cutting edge research in biology, agriculture, food sciences, psychology and pharmacy. Some prior experience with the systems and methods to be employed will be an advantage, but is not essential as full training will be given.
Funding supports PhD and bench fees, a stipend of £13,590 p.a. in addition to an allowance for conferences, travel, training and all direct project-related costs for UK/EU students.
Dr B. Whalley (email@example.com)