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Biomarker Experimental Medicine Leader - Neuroimaging Statistical Scientist
- Vacancy Reference Number
- 202007-119997
- Closing Date
- 7 Oct 2020
- Address
- Switzerland, Basel-City, Basel
Job details
At Roche, we believe it is urgent to deliver medical solutions now – even as we develop innovations for the future. We are passionate about improving the lives of patients with brain diseases and strive for ambitious ideas, innovative approaches and urgent action. Our belief is that our success as a company will come from developing therapies for patients in need, which is why we come to work every single day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.
Within Roche’s Pharma Research and Early Development (pRED), Neuroscience & Rare Diseases represents a major focus area where we are committed to realizing our long-term vision of changing lives of patients with severe brain disorders. Our preclinical research and early clinical development activities center around large and rare indications within the four major pillars of neurodevelopmental disorders, movement disorders, dementia, and multiple sclerosis. With unparalleled strengths across diverse disciplines, Roche is uniquely positioned to lead in transforming science to medicines for patients with disorders of the nervous system.
To achieve our goals, Roche pRED Neuroscience & Rare Diseases is currently undergoing a major and exciting recruitment effort for a large number of new positions including a Biomarker Experimental Medicine Leader - Neuroimaging Statistical Scientist in the BTT. All positions are based in Basel, Switzerland.
This role is within the BTT group focused on the development and application of molecular and imaging biomarkers to support clinical testing of novel treatments for neurodegenerative, neurodevelopmental, autoimmune, and rare genetic diseases of the central nervous system.
You will be responsible for the delivery of biomarker strategies encompassing molecular imaging, genetics and fluid biomarkers, translating from preclinical through the early stage of clinical development. In addition, you will coordinate developments and validation of biomarker assays across these modalities, in order to provide tools for compound evaluation and patient stratification throughout the phases of drug development.
Requirements
- PhD in physics, computational medicine, neuroscience or related discipline.
- Good understanding of molecular biomarkers and clinical imaging methodology
- Experience with statistical analysis of imaging endpoints in pharma clinical trials
- Capacity to work effectively in multidisciplinary teams, proactive attitude, problem-solving capacity and ability to work independently
- Ability to process and analyze PET and MRI data
- Experience with statistical packages (e.g. Matlab and R) and neuroimaging software (e.g. SPM, FSL, PMOD)
- Excellent oral and written communication skills in English are required.
Desirable skills
- Publication record in neuroimaging or related field
- Experience in biomarker strategy development and implementation in pharma trials
- Good understanding of the drug discovery and development process including GCP regulations
- Knowledge of GCP imaging SOP development and all aspects related to study QC/calibration and standardization
- Proven track record of leading the development and execution of clinical imaging studies (PET or MRI) to support neuroscience drug development
- Experience of working with academic imaging labs and CRO’s
- Strong influencing skills: proven abilities to get things done without formal authority
- Good team interaction skills
How to apply