Epilepsy Gene Therapy

Vacancy Reference Number
Closing Date
9 Jul 2021
£36,028 - £43,533 per annum
UCL Queen Square Institute of Neurology London WC1N 3BG United Kingdom
36 months in the first instance
The post holder will develop, test and optimize novel molecular tools to manipulate the excitability of discrete brain regions involved in seizure initiation and propagation. The project is central to an MRC-funded programme of research aimed at optimizing gene therapy for refractory epilepsy, with a view to clinical translation. It will be supervised by DM Kullmann, MC Walker, S Schorge (UCL Department of Neuroscience, Physiology and Pharmacology) and G Lignani. Although the post is based in the Research Department Clinical and Experimental Epilepsy (UCL Queen Square Institute of Neurology), the successful applicant may be asked to work in the Department of Neuroscience, Physiology and Pharmacology (NPP). Applicants should have a PhD (or be close to obtaining) or equivalent in Neuroscience or a related discipline. Experience of in vitro or in vivo electrophysiology, working with rodents, colony maintenance and surgery is essential as is in-depth knowledge of molecular biology methods. IT proficiency at advanced user level (electrophysiological and imaging data processing, statistical analysis programs), good inter-personal skills with an ability to work co-operatively in a multidisciplinary setting and strong problem-solving abilities are also required. Experience with neuronal cultures and/or ex vivo brain slice preparations, immunofluorescence and confocal microscopy is desirable, as is a Personal Licence from the UK Home Office to work with rodents.

Further Information

www.ucl.ac.uk/hr/jobs reference: 1876727 or https://t.co/b14Y5MYvH7

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