The student would be based in the Living Systems Institute at the Streatham Campus Exeter.
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons i.e. nerves that convey signals from the brain and spinal cord to the muscles. ALS patients display progressive loss of motor neurons, suffer increasing immobility with paralysis, and eventually die from respiratory failure. So far, there is no cure for this fatal disease. This proposal aims to investigate the molecular interactions between noncoding RNAs (ncRNA) and aging in the context of ALS-associated motor neuron degeneration.
The project will involve developing 3D models of neurodegeneration using patient-derived iPSC and CRISPR edited isogenic controls. The student will learn cutting edge cell biology techniques to develop these disease models. Further, these models will be investigated at the molecular level using state-of-the-art genomics tools. The student will gain training in stem cell based disease modelling, genomics as well as high-content microscopy based screening. The project is expected to have a significant impact on advancing our knowledge regarding ALS and potentially take us a step closer to finding a therapy for this devastating disease.
This award provides annual funding to cover UK/EU tuition fees and a tax-free stipend. For students who pay UK/EU tuition fees the award will cover the tuition fees in full, plus at least £14,777 per year tax-free stipend. Students who pay international tuition fees are eligible to apply, but should note that the award will only provide payment for part of the international tuition fee and no stipend.
The studentship will be awarded on the basis of merit for 3.5 years of full-time study to commence in November 2018 and is subject to confirmation of funding.
For more information and to apply, click here
