PhD Mathematical Modelling of Brain Haemodynamics and Pressure-Volume Compensation

Closing Date

5 Dec 2018

Address

Department of Clinical Neurosciences, University of Cambridge

Duration

3-4 years

Project Description

Dynamical properties of cerebral blood flow (CBF) and cerebrospinal fluid circulation (CSF) can be modelled by a structure of nonlinear differential equations (1). Models describe such phenomena as autoregulation of blood flow, brain venous blood outflow, compensatory role of CSF circulation, etc (2). They are relevant to understanding of pathophysiological mechanisms after traumatic brain injury, subarachnoid haemorrhage, stroke, in hydrocephalus and in idiopathic intracranial hypertension. Database of recorded clinical signals is available for verification or identification of successful modelling structures. Project will be focused on further refinement of the existing models, including their application for non-invasive assessment of intracranial pressure (3), asymmetry of CBF and phenomenon related to collapse of cerebral venous sinuses. Project suits neuroscientists with strong computer skills (including writing own codes, advanced Matlab, etc). 
 

Funding Notes

Funding deadline is 5th December 2018 for start in October 2019. When applying indicate on the application the funding options (GATES USA *deadline 10/10/18*, Gates Cambridge or other Cambridge Funders). Home/EU and International applications are all considered for funding. 
Further information can be found on the website View Website

References

Further readings (4). 1. Czosnyka et al. J Neurol Neurosurg Psychiatry. 1997 Dec;63(6):721-31. 2. Piechnik et al. J Cereb Blood Flow Metab. 2001 Feb;21(2):182-92. 3 Kashif FM et al. Sci Transl Med. 2012;4(129):129ra44. 4.http://www.neurosurg.cam.ac.uk/pages/brainphys/index.php

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