PhD Studentship in Cellular Neuroscience

Vacancy Reference Number

975018BJ

Closing Date

26 Mar 2018

Salary

£14,777 per annum

Address

Life Sciences Building, University of Southampton, Southampton, UK

Duration

3 years

Project title: What is the limiting step in pathogenic tau transmission along neuronal networks? Neurofibrillary tangles formed of misfolded tau protein are found in a range of neurodegenerative diseases. Self-propagation of the conformational change across the brain contributes to disease progression, however, the cellular mechanisms underlying the transmission of toxic protein species are not well understood. This project will dissect the earliest steps of seeded misfolding using biochemical and cell biological techniques. These will include the use of fluorescent and bioluminescent reporter assays and microfluidic co-culture platforms developed by the group. Experience in cell biology and/or molecular biology will be essential, with a background in neuroscience desirable.

Further Information

The project is funded for 3 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. For further information and application guidelines, see: https://jobs.soton.ac.uk/Vacancy.aspx?ref=975018BJ

Contact Details

General enquiries should be made to Katrin Deinhardt at: K.Deinhardt@soton.ac.uk. Any queries on the application process should be made to pgafnes@soton.ac.uk.

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