Postdoctoral Scientist – Neurobiology Cell Models

Closing Date
24 Oct 2021
Medicines Discovery Catapult, Cheshire, SK10 4ZF
1 year

Based at Alderley Park, Medicines Discovery Catapult is a national facility connecting the UK community to accelerate innovative drug discovery. They provide unique scientific capabilities and act as a gateway to UK resources and expertise, supporting UK SMEs to drive the development and industrialisation of new approaches for the discovery of new medicines. By validating new ways of discovering medicines and driving key talent and expertise across the sector, we will support the UK life sciences industry, SMEs and innovators to deliver growth for the UK economy and maintain the UK’s heritage position as a global leader in medicines R&D.

The role of Postdoctoral Scientist - Neurobiology Cell Models, in the MDC Discovery group, would suit a highly motivated self-starter who is passionate about the application of iPSC derived astrocytes, microglia and neurons in complex cell models to recapitulate aspects of disease biology. Working in an interdisciplinary team, the successful candidate will apply their expertise in iPSC cell culture, neurobiology, and associated methods to deliver impactful results to both collaborative projects with an external partners and internal innovation projects. Through the application of cell imaging and functional assays, the candidate will characterise the response of CNS cell types in complex cell models and execute cellular target engagement and target validation studies. The opportunity to join a world class laboratory team in this high-profile national organisation, and contribute your ideas, insights, and creative science to a highly innovative, collaborative projects should provide a fantastic platform for career development. 

Main duties and responsibilities:  

  • Apply iPSC biology expertise in the growth and maintenance of various cell types including iPSCs, neural progenitors, and astrocytes, microglia, and neurons to support the delivery of projects
  • Support the complex cell model team to design and deliver strategies to evaluate phenotypic responses of cell types in monoculture, co-culture and tri-culture including the assessment of compound efficacy
  • Deliver high quality data in a complex and time pressured research team environment
  • Contribute scientific insight and innovative technical approaches for more successful drug discovery programmes
  • Demonstrate effective communication and research collaboration skills
  • Maintain excellent written records of work