Dementia is the biggest health challenge of our century.
The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill this gap.
The team at the UK DRI at King’s College London maps out the earliest changes in the brain associated with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) in cellular and animal models and in people to gain a much deeper understanding of the causes of these conditions. Research focuses on the misfolding and aggregation of the protein TDP-43 with the aim of uncovering the fundamental mechanism common to several protein misfolding disorders to inform the development of therapies for multiple forms of dementia.
The role holder will study of the consequences and key pathways of Tau phosphorylation (pTau) on molecules associated with postsynaptic function in the brain. They will undertake electrophysiology in brain slice, optogenics and multi-photon confocal microscopy.
Person criteria
You will have expert knowledge of glutamate receptors and synaptic plasticity along with knowledge of two-photon imaging systems and excellent technical skills in patch clamp recording and brain slice cell culture. You'll have completed a PhD in a relevant area of neuroscience or neurobiology, have published significant work in your research field, and have good interpersonal and communication skills.
For more information and to apply, please click here.
Contact Person : Professor Kei Cho Contact Details : kei.cho@kcl.ac.uk
