Research Associate in Epigenetics (Imperial)

Vacancy Reference Number
Closing Date
26 Nov 2021
£41,593 – £49,210 per annum plus benefits
UK Dementia Research Institute, Department of Brain Sciences, Imperial College London
1 year (possible extension for further 5 years)

Dementia is the biggest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

The UK DRI at Imperial brings together researchers from diverse backgrounds with fresh perspectives, drawing on the university’s unique strengths, resources and focus on science, engineering, medicine and business. The team recognises that the challenges of dementia demand new concepts, new approaches and a diverse range of new research tools and directions. Their holistic approach views the ageing brain in the context of the ageing body, not in isolation.

The research group of Dr Nathan Skene in the UK DRI at Imperial College London addresses key questions about the mechanisms of neurodegenerative disease.  In a series of recent publications in Nature Genetics, the lab has demonstrated that single cell RNA-seq data from mice can be used to identify the cell types associated with genetic risk factors for neurodegenerative disease. We aim to develop single cell epigenetic techniques, such as ATAC-seq and CUT&TAG, to enhance our ability to map intergenic loci to cell type specific features.


Duties and responsibilities

To work collaboratively as part of a multidisciplinary research team

To learn and apply suitable techniques for the analysis of complex genomic data

To conduct and interpret data analysis, and prepare suitable summary outputs of the analysis

To maintain accurate and complete records of all findings using electronic notebooks and version-controlled systems

Work with PIs to develop novel research concepts, approaches and tools

Integrate multiple methods as part of well-designed research plans that efficiently address and resolve fundamental research questions

Creatively adapt available tools or resources to meet experimental challenges

Seek and lead on external collaborations to harness additional external expert resources or tools

Contribute to management of the research groups and laboratory spaces in a responsible and collegial fashion

Deliver regular reports of research to the PI, within the UK DRI Centre and externally at national or international meetings

Lead in preparation of research outcomes for publication


Essential requirements

Research Associate: Hold a PhD (or equivalent) in Biochemistry, Molecular Biology or a closely related discipline, or equivalent research, industrial or commercial experience

Research Assistant: Near completion of a PhD (or equivalent) in Biochemistry, Molecular Biology or a closely related discipline, or equivalent research, industrial or commercial experience

Evidence for mastery of laboratory-based molecular biology skills

Experience with some genomic techniques including but not limited to ATAC-seq, RNA-seq, DNase-seq, MNase-seq, CUT&TAG, CUT&RUN, Radicl-seq or Hi-C.

Applicants are strongly encouraged to contact Dr Nathan Skene for informal discussion about the role at