We are seeking an ambitious and highly motivated post-doctoral scientist to work in a programme of research that aims to investigate novel drug targets in alpha-synuclein pathobiology. The study will involve the study of iPSC-based models using CRISPR/Cas9. Ad such the post will offer an excellent opportunity for mechanistic research and drug target identification in Parkinson’s disease using state-of-the-art models and facilities at the Nuffield Department of Clinical Neurosciences at the University of Oxford.
The post-holder will also benefit from and be exposed to interactions with Industry and work alongside a multidisciplinary team in the Molecular Neurodegeneration Research Group. They will use established lab protocols to differentiate iPSC into neurons and analyse scientific data to test new hypotheses and generate new constructs relevant to the project using CRISPR.
It is essential that the successful candidate hold or be nearing completion of a PhD/DPhil and they have a proven track record in cell culture, ideally iPSC-based models and imaging. It is also crucial that they have previous use of biochemical techniques in mechanistic studies and have a proven track record in molecular biology.
It would be beneficial to the role if the postholder had knowledge of proteostasis pathways and had experience in modelling of protein aggregation. It would also be beneficial if they had previous experience in models of Neurodegeneration.
https://www.jobs.ac.uk/job/CEA572/research-associate-molecular-pathogenesis-of-parkinsons-disease
