Research Associate Optic Neuropathy - University of Cambridge

Vacancy Reference Number
Closing Date
15 Jul 2019
£32,236 to £39,609
Department of Clinical Neurosciences, University of Cambridge
Fixed term for 2 years in the first instance

We are looking to recruit a full-time postdoctoral research associate to join the laboratory of Dr Patrick Yu Wai Man (, Department of Clinical Neurosciences, University of Cambridge). 


Dr Yu Wai Man is leading a translational research programme focused on dissecting the disease mechanisms leading to progressive retinal ganglion cell loss in inherited optic neuropathies by using diseased patient tissues and animal models, in particular zebrafish.  The lab has access to a unique tissue biobank, including mutant induced pluripotent stem cells (iPSCs) established from patient-derived fibroblasts. The goal is to capitalise on this rich resource to push forward with therapeutic drug screening and early phase clinical trials, working in close collaboration with industrial partners. 

The Yu Wai Man group is making use of next-generation sequencing technology to identify novel disease causing genes in patients with inherited optic neuropathies. In addition to new gene discovery, the successful candidate will make us of cell-based and zebrafish disease models to further characterise the disease pathways contributing to optic nerve degeneration in this group of disorders, with a particular focus on Leber hereditary optic neuropathy (LHON), autosomal dominant optic atrophy (DOA) and Wolfram syndrome.

The Department of Clinical Neurosciences, which is based on the Cambridge Biomedical Campus was formed in 2004 and brings together the University Divisions of Neurology, Neurosurgery and Stem Cell Neurobiology, the John van Geest Centre for Brain Repair and the Wolfson Brain Imaging Centre. 

This project is an exciting collaboration that will provide the successful candidate with access to resources and expertise within the John van Geest Centre for Brain Repair and the MRC Mitochondrial Biology Unit. 

Fixed-term: The funds for this post are available for 2 years in the first instance. 

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check. 

To apply online for this vacancy and to view further information about the role, please visit :

Closing Date - 15th July 2019 

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. 

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager 

Please quote reference ZE18126 on your application and in any correspondence about this vacancy. 

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. 

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.