Research Associate - UK DRI, Cardiff

Vacancy Reference Number
Closing Date
11 Dec 2019
£33,797 - £40,322 per annum
UK DRI at Cardiff, Cardiff, CF14 4XN
2 years

About the job

Dementia is the biggest health challenge of our century. 

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill this gap. 

Colleagues at Cardiff University have discovered over 27 risk genes for dementia which implicate the innate immune response in determining a person’s susceptibility to developing Alzheimer’s disease. Building on their world-class expertise in genetics and immunology, the UK DRI at Cardiff University will use these discoveries as the starting point for understanding disease mechanisms and producing new therapies. 

Prof Vincent Dion’s lab has recently developed a novel method to contract expanded CAG/CTG repeats using the CRISPR/Cas9 nickase, thereby correcting the mutation that causes 14 different diseases.

We are seeking a passionate, hard working, and creative Research Associate (Postdoc) who will test whether our gene editing approach is applicable to myotonic dystrophy type 1 and to assess the extent of off-target mutations caused by this treatment in induced pluripotent stem cells.

The work will have important implications to the design of novel therapeutic avenues for this group of debilitating neuromuscular and neurodegenerative diseases.

Person criteria

The successful candidate will be highly independent and drive the project to its fruitful completion. Expertise in molecular biology, tissue culture, including induced pluripotent stem cells, and/or CRISPR technology are essential. Experience of high-throughput sequencing and its analysis are highly desirable.

For more information and to apply, please click here. 

Contact Details