Research Associate - UK DRI

Vacancy Reference Number

12722BR

Closing Date

1 Dec 2021

Salary

£34,304 to £40,927 per annum

Address

UK DRI, Cardiff

Duration

3 years

Dementia is the greatest health challenge of our century

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

The UK DRI at Cardiff is one of 7 UK centres bringing together world-leading scientists to deliver a step-change in the scientific understanding of dementia, generating new targets for drug development, reinvigorating the therapeutic pipeline and helping to transform care.

The UK Dementia Research Institute (DRI) at Cardiff are looking to appoint a Research Associate. The position will be in the group of Prof Philip Taylor, UK DRI at Cardiff.

The post is funded by the UK DRI and is a collaborative project between the Cardiff and Edinburgh UK DRI centres and Oxford University. The successful candidate will join a well-funded group and use cell biology, single cell RNA sequencing and informatics to characterise iPSC-derived microglia-like cells. Using state-of-the-art single cell sequence analysis and informatic approaches to establish a framework for the use human iPSC-derived microglial cultures in translational platforms. The project will be aligned to the UK DRI at Cardiff’s flagship IPSC Platform to Model Alzheimer’s Disease Risk (IPMAR), which will establish a panel of iPSC from people with high and low polygenic risk for Alzheimer’s disease. This project will establish the criteria by which iPSC microglia are evaluated for use within the research community.

Requirements

Candidates should have practical experience of cell biology (preferably, but not essentially, with experience in the culture of human iPSC). The project will involve a period of time at the Edinburgh UK DRI centre.

For further information candidates should contact Prof Philip Taylor TaylorPR@cf.ac.uk