Research Fellow

Vacancy Reference Number
1871849
Closing Date
1 Oct 2020
Salary
£35,965 - £43,470 per annum
Address
UK Dementia Research Institute at University College London, Queen Square
Duration
1 year in the first instance

Job Details

Dementia is the biggest health challenge of our century. To date, there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it. 

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap. 

Research from the UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test. 

The Bartels lab at the UK DRI at UCL is specialized and fills the gap for scientific research on synuclein multimers and lipidomics associated with PD in close collaboration with the National Hospital for Neurology and Neurosurgery and the Queen Square Brain Bank. The Bartels laboratory is dedicated to understanding the biochemical nature of α-synuclein in healthy and diseased patients.  Dr Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilization in Parkinson’s Disease.  His lab is interested in identifying the different factors that destabilize α-synuclein and that lead to neurotoxicity.  

The Bartels lab is seeking a Research Fellow. The research project will comprise the analysis of the cellular distribution and structural changes of α-Synuclein, a protein involved in neurodegeneration in live cells via microscopy. The project will use FCS, single molecule FRET, Optodroplet, FRAP and general confocal microscopy and will be conducted in collaboration with the David Klenerman lab at UK DRI Cambridge. 

Requirements

Applicants should have a PhD, MD or equivalent experience in Biophysics, Biochemistry, Molecular Biology or related discipline. Experience of working with Biophysics, Biochemistry, Molecular Biology or Histology assays is essential, as well as working with advanced microscopy techniques. Candidates should also have good interpersonal skills, resourcefulness, the ability to present complex scientific concepts and excellent communication skills.

Desirable skills

Neurodegeneration, liquid-liquid phase separation, synucleinopathies, biochemical analysis such as crosslinking and Western Blot, biochemical fraction and cell culture experience, especially neuronal differentiation of human stem cells and primary cells, and live cell microscopy.

How to appy

https://atsv7.wcn.co.uk/search_engine/jobs.cgi?amNvZGU9MTg3MTg0OSZ2dF90ZW1wbGF0ZT05NjUmb3duZXI9NTA0MTE3OCZvd25lcnR5cGU9ZmFpciZicmFuZF9pZD0wJnBvc3RpbmdfY29kZT0yMjQ%3D&jcode=1871849&vt_template=965&owner=5041178&ownertype=fair&brand_id=0&posting_code=224 

Contact details

Dr Tim Bartels: t.bartels@ucl.ac.uk