Winners of the BNA Credibility Prizes 2024
17th April 2024
Research Fellow
- Vacancy Reference Number
- 1871848
- Closing Date
- 1 Oct 2020
- Salary
- £35,965 - £43,470 per annum
- Address
- UK Dementia Research Institute at University College London, Queen Square
- Duration
- From October 2020 in the first instance
Job Details
Dementia is the biggest health challenge of our century. To date, there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.
The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.
Research from the UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test.
The Bartels lab at the UK DRI at UCL is specialized and fills the gap for scientific research on synuclein multimers and lipidomics associated with PD in close collaboration with the National Hospital for Neurology and Neurosurgery and the Queen Square Brain Bank. The Bartels laboratory is dedicated to understanding the biochemical nature of α-synuclein in healthy and diseased patients. Dr Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilization in Parkinson’s Disease. His lab is interested in identifying the different factors that destabilize α-synuclein and that lead to neurotoxicity.
The research project will involve developing antibodies against specific species of α-Synuclein, a protein involved in neurodegeneration, and develop an ELISA or Quanterix detection assay to detect α-Synuclein in different human biofluids (blood, CSF) and establish a fluid biomarker for Parkinson’s Disease and Dementia with Lewy Bodies.
The project will be conducted in collaboration with the Zetterberg lab at the UK DRI at UCL and Rimona Weil at the National Hospital for Neurology and Neurosurgery in Queen Square London.
Requirements
Applicants should have a PhD, MD or equivalent experience in Biophysics, Biochemistry, Molecular Biology or related discipline.
Experience of working in quantitative biological analytics (ELISA, Quanterix) and with antibody development and verification is essential, along with advanced level of IT proficiency, the ability to present complex scientific concepts, understanding of the mission of the UK DRI, being creative and a proactive thinker.
Desirable skills
Experience with handling human samples, with biomarker development, and of working with Biophysics/Biochemistry/Molecular Biology/Histology assays.
How to apply
Contact details
Dr Tim Bartels t.bartels@ucl.ac.uk