Job Details
Researchers at the UK DRI at Edinburgh aim to piece together how all the different brain cells, systems and processes work together to keep our brains healthy over many decades. Unravelling how these finely-tuned interactions are disturbed even before a person has any specific signs or symptoms of dementia – and how changes are involved in driving disease progression – will open new avenues for the development of novel therapies. We seek to recruit a talented and ambitious postdoctoral research fellow to investigate how neuroimmune changes triggered by stroke influence long-term cognitive function. The position is funded for four years by the Leducq Foundation through the Stroke-IMPaCT international network.
We aim to discover how immune cell changes early after stroke, in the brain and systemically, may dictate long-term immune-neuroglial cell interactions relevant to cognition. This project will be anchored around preclinical stroke models and through Stroke-IMPaCT there will be scope for complementary clinical investigations. You will use a range of in vivo, cellular, molecular and neuroimaging techniques to manipulate, track and measure immune cell and glial function and their interactions in combination with behavioural assays of cognitive function. Techniques may include lineage tracing, high dimensional single-cell resolution immunophenotyping and preclinical MR/PET neuroimaging.
The research fellow will be in the McColl lab, embedded within a rich local neuroscience, immunology and vascular research community co-located on a major biomedical and health research campus. The lab is part of the UK Dementia Research Institute. Opportunities for collaboration, data sharing, training, mentorship and lab exchanges will be extensive.
Requirements
Candidates need to have a PhD (or PhD near completion) or equivalent qualification in a relevant biomedical science and ideally, they will present deep knowledge, interests and skills in neuroimmunology, cerebrovascular disease and/or neurodegeneration. The successful candidate will work well independently and in a team. The selected applicant will have a key role in forming productive interactions with the other Stroke-IMPaCT network labs.
How to apply
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