Research Fellow (UCL – Duff Lab)

Vacancy Reference Number
Closing Date
26 Jan 2020
£35,965 - £43,470 per annum inclusive of London Allowance
UK DRI at UCL, London WC1E 6BT
Funded for two years in the first instance

Dementia is the greatest health challenge of our century.

The UK Dementia Research Institute (UK DRI) is the biggest initiative supporting research to fill this gap.

Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test.

The Duff lab is looking for a highly-motivated, experienced and self-driven individual to work on an exciting project that aims to examine the mechanisms underlying tau pathogenesis in Alzheimer's and FTD.  

The successful applicant will apply novel, sophisticated in vitro, ex vivo and in vivo approaches to track and examine the role of tau in disease cases in human and mouse models and cell model systems. 

In addition, the candidate will explore the mechanisms by which tau aggregates spread through the brain, and ways to prevent spread, to generate an understanding of how best to create disease-relevant assays.

Person criteria

The successful candidate will hold, or be close to obtaining, a PhD in biological science. 

Experience in molecular/cellular neurobiology, especially of the pathogenic processes underlying Alzheimer's and Frontotemporal dementia linked to tau, developing and implementing high resolution, single cell or molecule techniques for assessing tau and related proteins in human, mouse and/or cell samples, and working with human derived samples is essential. 

A proven level of technical skill in assessing tau or other disease associated proteins, and abilities in assessment of ultra-low levels of proteins, immunohistochemistry/immunofluorescence, biochemical and molecular biology techniques, excellent oral and written communication and inter-personal skills, and a commitment to working ethically, legally and with integrity are also required.

Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £31,965 - £33,194 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.If the PhD has not yet been granted, the final accepted version of the thesis must have been submitted to the degree-granting university by the start date.

Contact Details

If you have any queries regarding the application process, please contact Miss E Bertram, HR Manager, UCL Queen Square Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email:

For informal enquiries about the role, please contact Karen Duff (email: