Research Technician (UCL)

Vacancy Reference Number
1870591
Closing Date
20 Aug 2020
Salary
£29,089 - £34,090 per annum
Address
UK DRI at UCL, Queen Square
Duration
For the period to 31 August 2021 in the first instance

Job details:

Dementia is the biggest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

Research from the UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test.

The Bartels laboratory at the UK DRI is dedicated to understanding the biochemical nature of α-synuclein in health and diseased patients.   Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilization in Parkinson's Disease.  His lab is interested in identifying the different factors that destabilize α-synuclein and that lead to neurotoxicity.

We are now looking for a Research Technician to provide technical assistance and experimental support for several projects ongoing in the Bartels lab, analysing human post mortem brain material and various cell culture models including iPSC-derived and primary human neurons as well as structural in vitro assays using recombinant protein.   The native brain tissue and the in vitro models will be used to study α-synuclein multimers and lipid composition in different Synucleinopathies.  In vitro, aggregation assays, electronmicroscopy, CD spectroscopy and FCS will be used to eludicate context dependent folding.

 

Person criteria: 

Applicants must have Honours degree (minimum 2:1) or equivalent in Biophysics/Biochemistry/Molecular Biology or a related discipline and experience of working with Biophysics/Biochemistry/Molecular Biology/Histology assays.   Excellent oral and written communication and good inter-personal skills with an ability to work co-operatively in a multidisciplinary setting are also required.

 

 

Contact Details

t.bartels@ucl.ac.uk