Senior Research Technician Neurodegenerative Disease - University College London

Vacancy Reference Number
Closing Date
19 Jun 2019
£35,328 to £42,701 per annum including London Allowance
UCL Institute of Neurology, UK Dementia Research Institute and Department of Neurodegenerative Disease, UCL Institute of Neurology
Fixed term until 30th September 2022 in the first instance

Applications are invited for a Senior Research Technician. The post is within the Department of Neurodegenerative Disease although it is based entirely at the UK Dementia Research Institute at UCL. A GGGGCC (G4C2) repeat expansion in C9orf72 is the most frequent genetic cause of the devastating neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In order to further understand disease mechanisms we have generated novel DPR knock-in mouse models. The central aims of this post will be to characterise these, and other, new models using molecular, biochemical and histology techniques.

Experimental approaches will include genotyping using both PCR and Southern blotting, immunostaining, microscopy and image analysis, western blotting and quantitative PCR. The successful candidate will also have the opportunity to utilize the breadth and depth of expertise and technologies available across the collaborating groups, and the Dementia Research Institute at UCL.

The successful candidate will have a BSc or a PhD or equivalent experience in life sciences research. Experience with molecular, biochemistry and histology techniques and with mouse colony management and genotyping is essential. Applicants must have comprehension of basic statistical analysis methods, knowledge of scientific terminology, excellent oral and written communication skills and ability to communicate and deal effectively and professionally (ie, with tact, diplomacy and sensitivity) with a wide range of people at all levels in and outside the University. The ability to manage a cycle of projects from inception to completion and demonstrable organisational skills with a methodical and accurate approach are also required. An understanding of neuroscience and neurodegenerative diseases is desirable.

The post is available immediately and is funded from UK DRI @ UCL until 30th September 2022 in the first instance. The post is graded as UCL Grade 7 with salary in the range £35,328 - £42,701 per annum including London Allowance.

You should apply for this post through UCL's online recruitment site –  where you can download a job description and person specification using ref: 1809214.

If you have any queries regarding the application process, please contact Oksana Shapoval, HR Officer, UCL Queen Square Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email:

For enquiries about the role please contact Prof. Adrian Isaacs (

Closing date: 19 June 2019

We particularly welcome applications from black and minority ethnic candidates as they are under-represented within UCL at this level.

We will consider applications to work on a part-time, flexible and job share basis wherever possible.

For more information and to apply, click here

Contact Details

Oksana Shapoval, HR Officer:
Prof. Adrian Isaacs: