New expert-led consensus to shape the future of MND drug discovery and development research
6th December 2023
The Bartels lab is seeking to recruit two Research Fellow positions at the Dementia Research Institute. The Bartels lab at DRI is specialized and fills the gap for scientific research on synuclein multimers and lipidomics associated with PD in close collaboration with UCL, the National Hospital for Neurology and Neurosurgery, and the Queen Square Brain Bank. The Bartels lab is dedicated to understanding the biochemical nature of α-synuclein in healthy and diseased patients. Tim Bartels first discovered disease-resistant forms of the α-synuclein protein and their destabilization in Parkinson’s Disease. His lab is interested in identifying the different factors that destabilize α-synuclein and that lead to neurotoxicity.
The research project will comprise the analysis of human post mortem brain material and various cell culture models including iPSC-derived and primary human neurons as well as structural in vitro assays using recombinant protein. The native brain tissue and the in vitro models will be used to study α-synuclein multimers and lipid composition in different Synucleinopathies. In vitro, aggregation assays, electron microscopy, CD spectroscopy and FCS will be used to elucidate context dependent folding.
Applicants must be educated to PhD or MD level or have equivalent experience in Biophysics/Biochemistry/Molecular Biology or a related discipline, and have a very broad scientific background and knowledge including one or more of the following: Neuropathology, histopathology techniques, neurology and movement disorders/synucleinopathies in particular, biochemical analysis such as crosslinking and Western Blot, RNA and DNA analysis and cell culture experience, especially neuronal differentiation of human stem cells and primary cells, and biophysical assays such as CD spectroscopy, NMR, electron microscopy. Experience of working with Biophysics/Biochemistry/Molecular Biology/Histology assays is essential. Excellent oral and written communication skills, including presenting complex scientific concepts and content, an aptitude for proactive and creative independent thought, and good inter-personal skills are also required. Experience in stem cells, fluorescence correlation spectroscopy and PMCA/RT-Quic techniques is particularly desirable.
The posts are available from October 2018 and are funded for the period to August 2021 in the first instance by grants from DRI@UCL, Parkinson’s Foundation, and APDA. Starting salary on UCL Grade 7 in the range £35,328 - £42,701 per annum (including London Allowance).
You should apply for this post through UCL's online recruitment – www.ucl.ac.uk/hr/jobs where you can download a job description and person specification using ref: 1750562.
If you have any queries regarding the application process, please contact Elizabeth Bertram, HR Manager, Institute of Neurology, 23 Queen Square, London, WC1N 3BG (email: ion.hradmin@ucl.ac.uk).
Closing date: 12 October 2018
UCL Taking Action for Equality
We will consider applications to work on a part-time, flexible and job share basis wherever possible
For more information and to apply, click here
ion.hradmin@ucl.ac.uk