Project information
Dementia is the biggest health challenge of our century - currently affecting fifty million people worldwide, projected to triple by 2050, with huge financial, emotional and social impact on people directly affected, their carers, families and the community.
Dementia is a symptom of several neurodegenerative disorders, with Alzheimer's disease accounting for about 60% of cases. To date there is no way to prevent or even slow the rate of progression of neurodegeneration - there is still a major knowledge gap in our basic understanding of the diseases.
The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill this gap.
Researchers at the UK Dementia Research Institute at King's College London are using innovative approaches to explore the biological mechanisms involved in neurodegenerative diseases. Their goal is to defeat dementia by uncovering vital new knowledge that will lead to the design of smarter diagnostics and effective treatments. The team aims to understand the fundamental biological processes involved in dementia at a molecular level - and to use that knowledge to design new ways to diagnose and treat disease more precisely.
The UK Dementia Research Institute (DRI) groups of PD Dr Marc-David Ruepp (UK DRI at King's College London) and Prof Giovanna Mallucci (UK DRI at Cambridge) and are seeking a Postdoctoral Research Associate for a 3-year collaborative project. The UK DRI is a national consortium focused on cutting-edge dementia research funded by the Medical Research Council, Alzheimer's Society and Alzheimer's Research UK (www.ukdri.co.uk).
The project aims at characterising the physiological and neuroprotective roles of the RNA binding protein RBM3, key to the cold shock response. The postdoctoral research associate will start with the characterisation and validation of the RBM3 RNA and protein interactomes in the group of Marc-David Ruepp at King's College London (https://ukdri.ac.uk/team/marc-david-ruepp), followed by cellular and in vivo validation experiments of key candidate interactors in the group of Giovanna Mallucci at Cambridge University (https://ukdri.ac.uk/team/giovanna-mallucci).
Applicant criteria
We are looking for a candidate with good knowledge in molecular biology/biochemistry, RNA biology and mammalian cell culture that is keen to work across the King's College London and University of Cambridge UK DRI centres. In vivo experience in mice is desirable but not essential at this stage. Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered.
How to apply
https://jobs.kcl.ac.uk/gb/en/job/008044/UK-DRI-Cross-Centre-Postdoctoral-Research-Associate
Contact details
Marc-David Ruepp (King’s College): marc-david.ruepp@kcl.ac.uk
Giovanna Mallucci (Cambridge): gm522@cam.ac.uk
