Afternoon Session
We investigated how the SSRI fluoxetine affects intracellular signalling in astrocytes. Fluoxetine increases astrocytic cAMP through coordinated activation of 5-HT2B and adenosine A2B receptors by enhancing ATP release, which microglia convert to adenosine. These findings reveal a glia-mediated mechanism of antidepressant action involving astrocyte–microglia signalling.