Professor Dame Pamela Shaw

Director of the Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield

Professor Dame Pamela Shaw is an academic neurologist and internationally recognised leader in motor neuron disease (MND) research. She is Director of the Sheffield Institute for Translational Neuroscience (SITraN) and Director of the University of Sheffield Cross-Faculty Neuroscience Institute, and has held major leadership roles across national and international research organisations, including the NIHR and the Association of British Neurologists.

Her research focuses on translating discoveries in genetics and disease biology into new treatments for neurodegenerative disorders. She has made major contributions to MND research, including advancing neuroprotective therapies, improving clinical management through the use of non-invasive ventilation, and helping to define the genetic and molecular basis of the disease. Her work has supported the development of novel therapeutic targets, biomarkers, and gene-therapy approaches now progressing towards clinical trials.

Professor Shaw has authored more than 560 publications, secured over £140 million in research funding, and mentored more than 190 clinicians and scientists. Her contributions have been recognised with numerous international awards and a DBE for services to neuroscience.