Speakers
Morning Session
Menopausal hormone therapy (MHT) containing estrogens during menopause can improve many climacteric symptoms, including brain fog and mood disturbances, however traditional MHT can be unsuitable for many people due to off-target peripheral effects. We investigated the potential for a brain specific estrogenic prodrug (DHED) to improve cognitive function in a model of surgical menopause in young and middle-aged mice. We show that spatial, working and recognition memory are improved following DHED treatment and demonstrate the potential of brain specific MHT as a future therapeutic direction for menopausal symptom relief.