- Vacancy Reference Number
- B02-06132
- Closing Date
- 3 Jan 2024
- Salary
- £42,099 - £49,263 (inclusive of London weighting), depending on experience
- Address
- Centre for Advcanced Biomedical Imaging, Division of Medicine, University College London, Paul O'Gorman Building, 72 Huntley Street, London
- Duration
- 20 months
About us
The research group of Dr Ian Harrison (https://www.harrison-lab.co.uk/) is seeking a research fellow to carry out a project which aims to investigate the effects of novel therapeutic strategies targeting the glymphatic system in the brain. The position will be based within UCL’s Division of Medicine, at the Centre for Advanced Biomedical Imaging (CABI) (https://www.ucl.ac.uk/centre-for-advanced-biomedical-imaging/), a world-leading laboratory for in vivo imaging of glymphatic function in preclinical models. CABI is almost unique in its provision of experimental imaging apparatus, all housed in a bespoke facility in central London.
UCL is currently ranked second in the world, and first in Europe for neuroscience and behaviour, by Thomson ISI Essential Science Indicators, with more than twice as many publications and citations as any other European institution. UCL Neuroscience researchers generate over 30% of the country's contribution to the most highly cited publications in neuroscience, more than twice as much as any other university.
About the role
The project is focussed on understanding the effects of novel therapeutic strategies in animal models of Alzheimer’s disease, namely a tau propagation model. The role will involve inducing propagating pathology in transgenic animal lines using stereotaxic injection and studying the effects of drug treatments on this propagation. The project will therefore involve numerous in vivo techniques, including stereotaxic injections and surgical interventions, pharmacological treatments, cognitive behavioural testing, and magnetic resonance imaging, and numerous downstream cellular and molecular analysis techniques such as PCR, Western blotting and immunohistochemistry, as well as image processing and analysis.
The post is available from 1st January 2024 or as soon as possible thereafter, funded by AstronauTx, for a period of 20 months, in the first instance.
Please note that appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B with payment at Grade 7 being backdated to the date of final submission of the PhD thesis. If the PhD has not yet been granted, the final accepted version of the thesis must have been submitted to the degree-granting university by the start-date.
Please also note that appointment at Grade 7 is limited to the range from spinal point 30 to spinal point 36 and will depend on experience.
Further Information
About you
Applicants should be highly motivated and dedicated individuals with, or close to obtaining, a PhD or equivalent in neurodegeneration or a related neuroscience field. Extensive research experience with animal models of neurodegeneration and in vivo stereotaxic surgical is essential, as is a Home Office personal licence. Excellent oral and written communication and inter-personal skills, proven pro-active, creative and independent thinking and flexibility, and an ability to contribute ideas for new research projects are also required.
Contact Details
For informal enquiries, please do not hesitate to get in touch with Dr Ian Harrison (ian.harrison@ucl.ac.uk). If you need reasonable adjustments or a more accessible format to apply for this job online or have any queries about the application process, please contact Emilie Avisse (Senior HR Officer) at e.avisse@ucl.ac.uk.
