At AstraZeneca, we’re not afraid to do things differently. We’re building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening up new ways to work, pioneering cutting edge methods and bringing unexpected teams together.
Discovery Sciences is a multi-faceted department which drives early drug discovery across AstraZeneca’s global Innovative Medicines and Early Development (IMED) portfolio. Mechanistic Biology & Profiling (part of Discovery Sciences), is a global, multidisciplinary department responsible for mechanism-of-action studies and compound profiling for efficacy and pre-clinical safety in support of the Oncology, Cardiovascular, Renal & Metabolic Disease (CVRM), Respiratory, Inflammation & Autoimmunity (RIA), and Neuroscience portfolios.
As Associate Principal Scientist in the Safety Profiling & Ion Channel Pharmacology team within the Mechanistic Biology & Profiling Group in Cambridge, UK, you will pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.
Main Duties and Responsibilities:
You will be a lead scientist and part of a team generating in vitro ion channel pharmacology data to provide mechanistic insight for drug discovery targets, as well as providing pre-clinical in vitro safety profiling to predict and understand compound (and novel drug modalities) liability at key safety-related targets.
As Associate Principal Scientist, you will lead scientific initiatives within a high-performing team to provide early, impactful mechanistic pharmacology and safety insight to projects across the global IMEDs; you will achieve this through a combination of quantitative in vitro pharmacological approaches, comprising electrophysiology, high content imaging and ‘omics. You will be a credible lab-based scientist with expertise within the field of ion channel pharmacology and electrophysiology and have experience of developing physiologically relevant assays for compound profiling or mechanism of action studies for either drug safety or efficacy. You will have the ability to interact across a broad range of therapeutic projects and global initiatives within Discovery Sciences and IMEDs, as well as externally. You will represent the group on project teams and drive scientific and technical innovation, including through external collaboration and partnership.
This is an opportunity for a highly motivated scientist to work in a vibrant group to generate in vitro pharmacology data to provide mechanistic insight in support of both drug efficacy and safety.
Essential Requirements:
Desirable Requirements:
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