Episodic memory systems store the details of personal events from our past. How experiences are stored as episodic memories are across brain circuits is a major unanswered question. This project will identify and manipulate the changes in neural circuits that mediate storage of episodic memories. The focus will be on changes that take place in a part of the brain called the entorhinal cortex, which is a key site for formation of associations important for episodic memory.
Training will be provided in rodent models for investigation of memory, genetically encoded tools for marking activated neural circuits, optogenetic tools for manipulation of neural circuits, electrophysiological recording methods, whole-brain imaging and advanced data analysis tools.
Applications:
Completed application form along with your curriculum vitae should be sent to our PGR student team at RDSVS.PGR.Admin@ed.ac.uk
References:
Please send the reference request form to two referees. Completed forms for University of Edinburgh College of Medicine and Veterinary Medicine project should be returned to RDSVS.PGR.Admin@ed.ac.uk by the closing date: 5th December 2018.
It is your responsibility to ensure that references are provided by the specified deadline.
Download application and reference forms via:
https://www.ed.ac.uk/roslin/postgraduate/bbsrc-eastbio-dtp
Eligibility:
All candidates should have or expect to have a minimum of an appropriate upper 2nd class degree. To qualify for full funding students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.
Sürmeli G., Marcu D-C., McClure C., Garden D.L.F., Pastoll H. & Nolan M.F. (2015). Molecularly defined circuitry reveals input-output segregation in deep layers of the medial entorhinal cortex. Neuron 88(5):1040-1053. PMCID: 4675718.
Tennant S.A., Fischer L., Garden D.L.F., Gerlei K.Z., Martinez-Gonzalez C., McClure C., Wood E.R. & Nolan M.F. (2018). Stellate cells in the medial entorhinal cortex are required for spatial learning. Cell Reports, 22(5): 1313-1324.
Wilson, D.I.G., Watanabe, S., Milner, H., Ainge, J. A., 2013. Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory. Hippocampus 23, 1280–1290. doi:10.1002/hipo.22165
RDSVS.PGR.Admin@ed.ac.uk
