Background:
The astrocyte is one of the most numerous types of cell in the mammalian central nervous system (CNS). They are highly polarized and make contact with both synapses and endothelial cells of the vasculature, allowing them to modulate synapse function and cerebral blood flow by a variety of mechanisms.
The Project:
Whether these functional properties are shared by all astrocytes, or just subsets (in discrete brain regions), remains unclear and is an area of intense investigation in neuroscience. However, applying single cell transcriptome squencing methods, we have recently found several astrocyte subtypes in the adult mouse hippocampus.
The successful candidate will play a key role in developing intersectional genetic approaches (such as split Cre-) to specifically manipulate these astrocyte subtypes, catalyzing efforts to understand the developmental lineage and functionality of these cells.
The project represents an outstanding opportunity for an ambitious post-doc to establish themselves at the forefront of a developing field.
Requirements:
Candidates must have, or expect to obtain, a Ph.D. degree and be highly trained in modern molecular biology techniques. Experience in viral vector technology and/or generation of transgenic mouse lines is highly desirable.
What we offer:
The project will be conducted in the lab of Matthew Holt. The group has a strong international track record in studying the molecular basis of CNS function – and has been awarded 2 prestigious ERC grants to work on aspects of astrocyte biology.
The VIB Center for the Biology of Disease is an international research department with a strong emphasis on neuroscience. Researchers have access to high-end technologies, technical support and core facilities (including viral vector production and mouse genetics), all of which are housed in a new building.
A good knowledge of English is sufficient for all communications, both within and outside the institute. Situated in the heart of Europe (and with excellent transport links), the position is ideally suited to international candidates.
How to apply?
If you are a motivated and interactive individual, with a strong interest in applying intersectional genetics to a cutting-edge neuroscience question, please send your CV, a short letter of motivation and the names of three referees to Matthew Holt (Matthew.Holt@cme.vib-kuleuven.be).
Please send your CV, a short letter of motivation and the names of three referees to Matthew Holt (Matthew.Holt@cme.vib-kuleuven.be).
