Background:
F3 (or tissue factor) is a protein widely known for its role in blood coagulation. However, in the central nervous system (CNS), F3 is most heavily expressed in astrocytes. Astrocytes are a major cell type of the CNS - and play a number of important roles ranging from synapse formation and modulation of synaptic transmission, through to involvement in blood brain barrier formation and control of cerebral blood flow.
The Project:
Under normal circumstances, astrocytes should not come into contact with blood. Therefore, this project aims to understand the role of F3 in the CNS – and the underlying molecular pathways responsible for its function.
With access to a wide range of state-of-the-art techniques (such as quantitative mass-spectrometry through to in vivo imaging), this project provides an outstanding opportunity for an ambitious post-doc to establish a novel independent research line in the emerging field of astrocyte research.
Requirements:
Candidates must have, or expect to obtain, a Ph.D. degree and be highly trained in molecular biology and biochemistry techniques. A strong track record, as shown through multiple contributions to the scientific literature, is essential. Experience in mouse husbandry and use of the Cre-Lox system is desirable.
What we offer:
The project will be conducted in the lab of Matthew Holt. The group has a strong international track record in studying the molecular basis of CNS function – and has been awarded 2 prestigious ERC grants to work on aspects of astrocyte biology.
The VIB Center for the Biology of Disease is an international research department with a strong emphasis on neuroscience. Researchers have access to high-end technologies, technical support and core facilities (including mouse genetics, next generation sequencing (incl. single cell methodologies) and imaging). All facilities are housed in a new building.
A good knowledge of English is sufficient for all communications, both within and outside the institute. Situated in the heart of Europe (and with excellent transport links), the position is ideally suited to international candidates.
How to apply?
If you are a motivated and interactive individual, with a strong interest in understanding molecular mechanisms of CNS function, please send your CV, a short letter of motivation and the names of three referees to Matthew Holt (Matthew.Holt@cme.vib-kuleuven.be).
Please send your CV, a short letter of motivation and the names of three referees to Matthew Holt (Matthew.Holt@cme.vib-kuleuven.be).
