Job details
We seek a talented and passionate scientist to join the lab of Lucia Prieto-Godino (https://prietogodinolab.org/).
The lab employs a multidisciplinary approach to understand how neural circuits function and evolve, combining techniques that range from in vivo calcium imaging, electrophysiology, electron microscopy circuit tracing, single-cell RNA sequencing, genome editing, behavioural analysis, fieldwork and environmental chemical analysis. We are part of the Crick Neurophysiology group, a cluster of five neuroscience research groups.
The are several projects available, and the final project will be designed through discussions between the successful candidate and the group leader.
Some projects will investigate the evolution of odour processing through whole-brain volumetric in vivo two-photon calcium imaging in different Drosophila species in response to naturalistic odour stimuli. This project might also involve behavioural analysis and molecular biology.
Another project will investigate the mechanisms regulating transcriptional and proteomic diversity in neurons. We recently found prevalent neuronal-specific regulation of stop codon readthrough in Drosophila (Prieto-Godino et al. Nature 2016), suggesting a mechanism to generate alternative neuron-specific protein functions. The project will investigate how this process is regulated, its functional significance, and whether is conserved in vertebrates. This project will combine the power of Drosophila genetics with human induced pluripotent stem cells and advanced sequencing technologies, in collaboration with the Patani and Ule labs at the Crick.
Required skills
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
The set of required skills will depend on the final chosen project. However, a successful candidate will need to be an independent thinker, motivated to do science and able to work in a highly collaborative environment. In addition, they should be an expert in at least one of the following: two photon calcium imaging, Matlab, R, Python, Igor or similar programming languages, or experience analysing RNA-seq data, as well as with molecular and cell biology lab work.
Moreover, applicants need:
How to apply
The closing date for applications is 15 October at 23:45.
This is a full-time, fixed-term 4 years position on Crick terms and conditions of employment.
All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
