Research Assistant in Novel therapeutic targets in neuronal models of Parkinson’s

Closing Date
1 Dec 2021
£29,614 - £35,326 per annum
Kavli Institute for Nanoscience Discovery, Oxford
1 year

Applications are invited for a Research Assistant neuronal cell biologist to work on a new project developing disease-modifying therapies in patient stem cell-derived neuronal models of Parkinson’s. The project, in collaboration with EndLyz, a new company within the Dementia Discovery Fund (DDF) portfolio, represents an exciting opportunity to undertake translation work at the interface between academic research and pharmaceutical target and drug discovery in an exceptional setting. This work will develop novel therapies for Parkinson’s by better understanding the cellular and molecular mechanisms through working with induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson’s patients.

Duties will include undertaking laboratory experiments; interpretation of data; imaging analysis; generation and study of iPSC-derived neurons and cell lines; preparation of data for publication; study the mechanisms of action of modulators of the endolysosomal pathway in cellular models of Parkinson’s; contribute to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have excellent practical experience of working with induced pluripotent stem cell cultures and good knowledge of cellular models of neurodegenerative disease. Essential skills include the ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping.

Applicants must hold, or be near completion of, a BSc or MSc in a relevant area of research and have experience in cellular neuroscience or molecular cell biology relevant to analysis of neuronal phenotypes.

This post is fixed-term for 12 months, to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, New Biochemistry, Phase 2, Parks Road, Oxford, OX1 3PT.

Informal enquiries may be directed Professor Richard Wade-Martins Professor Richard Wade-Martins.

Closing date for applications is midday on Wednesday 1st December 2021. Interviews are likely to be held in the week commencing 6th December 2021.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion.