The UK Dementia Research Institute (UK DRI) is a joint £290 million investment from the Medical Research Council (MRC), Alzheimer’s Society and Alzheimer’s Research UK. Centered on the need for innovative, early-stage science to advance our understanding of how dementias develop and progress, the UK DRI’s research will bring new therapies to patients faster. The Institute’s mission is to find new ways to diagnose, treat and prevent dementias, whilst finding better ways to provide care for people with dementia.
Prof Vincent Dion’s lab has recently developed a novel method to contract expanded CAG/CTG repeats using the CRISPR/Cas9 nickase, thereby correcting the mutation that causes 14 different diseases. We are seeking a passionate, hard working, and creative Research Associate (Postdoc) who will test whether our gene editing approach is applicable to myotonic dystrophy type 1 and to assess the extent of off-target mutations caused by this treatment in induced pluripotent stem cells. The work will have important implications to the design of novel therapeutic avenues for this group of debilitating neuromuscular and neurodegenerative diseases.
The successful candidate will be highly independent and drive the project to its fruitful completion. Expertise in molecular biology, tissue culture, including induced pluripotent stem cells, and/or CRISPR technology are essential. Experience of high-throughput sequencing and its analysis are highly desirable.
This is a full time post (35 hours per week), availble 1st July 2019 and fixed term for two years.
Salary: £33,199 - £39,609 per annum (Grade 6)
Closing Date: Sunday, 23 June 2019
Please be aware that Cardiff University reserves the right to close this vacancy early should sufficient applications be received.
Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.
For more information and to apply, click here
