Research Associate Dementia - University of Cambridge

Vacancy Reference Number
Closing Date
19 Jun 2019
£32,236 to £39,609
Department of Clinical Neurosciences, University of Cambridge
Fixed term until 31 July 2021 in the first instance

Applications are invited for a research associate to join the team of Dr Emmanouil Metzakopian, in the newly established UK Dementia Research Institute (UK DRI) Centre at the University of Cambridge, Cambridge Biomedical Campus, Cambridge UK.

The mission of the UK DRI at the University of Cambridge, is to create a collaborative, inter-disciplinary Centre, combining world-leading expertise unique to Cambridge from chemistry, biophysics and structural biology with internationally leading research in the cell biology of neurodegeneration. This environment will enable creative and innovative approaches to the study of neurodegenerative disease and drive a gear change in our scientific understanding.

The scientific focus of the Centre is on understanding mechanisms involved in the earliest stages of neurodegenerative disease in order, ultimately, to deliver therapeutic targets with the greatest potential to prevent dementia. Three Foundation programmes led by DRI professors are complemented by three new programmes led by DRI Fellows (including Dr. Metzakopian) to develop this field.

The focus of the Metzakopian lab is on insights into novel neuroprotective mechanisms in neurodegeneration that provide new targets for treatments of these disorders.

This is a joint project between the Metzakopian and Balmus labs to identify novel neuroprotective pathways against oxidative stress. To perform this task we implement CRISPR-Cas9 genetic screens on in vitro Parkinson's disease models. We expect the candidate to be able to plan, perform and evaluate experiments, to generate targeted human induced pluripotent stem (iPS) cells, optimisation of CRISPR-Cas9 in iPS cell-derived dopaminergic neurons, and development of robust cellular assays.

Education to PhD level in a relevant subject is required. Knowledge of techniques in cell and molecular biology is essential although training in all relevant techniques will be provided. 

To learn more about the Metzakopian and Balmus labs please visit: and

For further enquiries please contact:

Fixed-term: The funds for this post are available until 31 July 2021 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy and to view further information about the role, please visit:

Closing Date - 19th June 2019

Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role.  If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager

Please quote reference ZE19168 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

For more information and to apply, click here

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