Research Associate in Neurobiology

Vacancy Reference Number
Closing Date
14 Aug 2022
£34,304 - £38,587
University of Bristol, Bristol, UK.

The role

We have a fantastic opportunity to join our growing team at the University of Bristol studying the neurobiology of torpor, and synthetic torpor-like states. Torpor is an extraordinary physiological state characterised by dramatic adjustments in thermoregulation, cardiorespiratory control, and even immune function. There is increasing interest in the possibility of inducing synthetic torpor in species for which it is not an extant behaviour - such as humans. We are an integrated group of clinicians and neuroscientists/physiologists who are particularly interested in torpor as a model of resilience, which might be mimicked to improve tolerance of organ dysfunction in critically ill patients. The project will build on work from this laboratory and elsewhere that identifies the preoptic area of the hypothalamus as a key centre for controlling entry into torpor in the mouse. The project has three core objectives:

  • Define the circuitry controlling torpor in the mouse
  • Explore the role of analogous circuits rats, which do not naturally enter torpor
  • Test whether centrally driven synthetic torpor in the rat is protective in models of acute lung injury.

What will you be doing?

This 3-year, MRC funded project will use cutting-edge neuroscience techniques, including: 'Targeted Recombination in Active Populations (TRAP)', opto- and chemo-genetic manipulations, in-vivo fibre-photometry, and tissue clearing and light-sheet microscopy. We also employ ex-vivo techniques including the working heart brainstem preparation, and the Langendorff beating heart preparation and phenotyping approaches including multiplex RNA in-situ hybridisation. The role will include performing recovery surgical procedures with stereotaxic injections and telemeter implantation; assays of autonomic, cardiorespiratory, and metabolic function; immunohistochemistry and in-situ hybridisation with light sheet microscopy, and preparation of professional communications.

You should apply if

We are looking for somebody with a PhD and experience in either neuroscience, rodent models of critical illness, or cardiorespiratory / metabolic research. Experience of single cell genetic analysis would also be of interest. We are looking for an enthusiastic, motivated, dynamic and effective individual to join the team working in this fast moving, translationally relevant topic.

Further Information

More information and how to apply here. 

Contact Details

For informal enquiries please contact Tony Pickering / Mike Ambler .