Job details
Dementia is the biggest health challenge of our century. To date, there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.
The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.
The UK DRI at Imperial College London brings novel, cutting edge approaches and research tools to the study of dementia to discover new disease mechanisms and therapeutic targets. The team focuses on the earliest pre-symptomatic stages of Alzheimer’s disease, addressing what determines the transition to neurodegeneration, and will investigate mechanisms that are likely shared across many of the dementias.
The fellowship programme of Dr Alexi Nott is focused on defining how the epigenome regulates cell type specific gene expression programs in ageing-related brain disorders using next-generation sequencing of patient-derived brain tissue and stem cell models of disease. These studies will help to guide the functional interpretation of noncoding disease risk variants for ageing-related brain disorders such as Alzheimer’s disease.
The UK DRI is seeking an outstanding post-doctoral researcher interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth.
Requirements
Successful candidates will be ambitious, with the passion to tackle big problems and a readiness to try out high-risk, high-payoff projects. Exceptional experience of genomic approaches, preferentially those pertaining to chromatin biology, is desirable and a background in molecular neuroscience would be advantageous.
How to apply
Contact details
Dr Jennifer Podesta: j.podesta@imperial.ac.uk?
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 - £38,566 per annum.
