Contract Type: Open Ended
Work Hours: 35.0 Hours per Week
Division/School: School of Biochemistry
We are looking for a self-motivated and talented scientist to study the role of altered microRNA activity on dendritic spine morphology and synaptic function in mouse models for Alzheimer’s disease. The project will build on our recent discovery that Argonaute 2 (Ago2) phosphorylation regulates the local translation of specific mRNAs and is required for structural and functional plasticity (Rajgor et al., EMBO Journal 2018).
The work will be based initially in the laboratory of Jon Brown at University of Exeter for in vivo molecular interventions (adenovirus and antagomir injections) and ex vivo slice electrophysiology. This will be followed by biochemical and cell imaging techniques in Jonathan Hanley’s lab in Bristol.
Applicants must have a PhD with relevant lab experience, and at least one 1st author article published in a quality peer-reviewed journal.
For informal enquiries please contact: Jonathan Hanley, +44 (0) 117 3311944, jon.hanley@bristol.ac.uk or Jon Brown, +44 (0) 1392 725504, J.T.Brown@exeter.ac.uk.
We appreciate and value difference, seeking to attract, develop and retain a diverse mix of talented people that will contribute to the overall success of Bristol and help maintain our position as one of the world’s leading universities.
For more information and to apply, click here
Jonathan Hanley:jon.hanley@bristol.ac.uk
+44 (0) 117 3311944
Jon Brown: J.T.Brown@exeter.ac.uk
+44 (0) 1392 725504
