Dementia is the greatest health challenge of our century.
The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill this gap.
Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test.
The Busche lab at the UK DRI at UCL is looking for an exceptional individual to head an industry-funded (Eisai) research project focused on uncovering the long-term effects of Alzheimer's Disease pathology on neuronal circuit and vascular functions in the intact brain in vivo, and through the use of mouse models, determining whether pathophysiology is reversible. The project will involve recording neuronal activity and vascular dynamics using head-mounted miniscopes and/or fibre photometry in freely behaving mouse models, manipulating circuits with opto- or chemogenetics, and integration of these techniques with behavioural testing and a variety of sophisticated interventions.
The post is available immediately and is funded by the UK DRI grant in collaboration with Eisai for a period of three years in the first instance.
The successful candidate will hold a PhD or equivalent in Neuroscience or a neuroscience-related or quantitative discipline (eg, physics, applied mathematics, engineering, bioinformatics). Experience in in vivo calcium imaging and/or electrophysiology and optogenetics, working with live mice, and with fibre photometry or miniscope imaging in freely behaving animals is essential. A strong statistical analysis background and programming and coding ability, excellent oral and written communication and inter-personal skills, and a commitment to working ethically, legally and with integrity are also required.
Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £31,965 - £33,194 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.If the PhD has not yet been granted, the final accepted version of the thesis must have been submitted to the degree-granting university by the start date.
For more information and to apply, please click here.
ion.hradmin@ucl.ac.uk
