Research Fellow UK Dementia Research Institute-UCL

Vacancy Reference Number

1874119

Closing Date

11 Feb 2021

Salary

£36,028 - £43,533 per annum per annum

Address

UK DRI at UCL, Queen Square

Duration

The post is available 1 February 2021 up to January 2023 in the first instance.

Job Details

Dementia is the biggest health challenge of our century. To date, there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

Research from the UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test. We are looking to appoint a highly-motivated and self-driven Research Fellow to lead an industry-funded (Roche) project focused at uncovering how microglia and neurons interact in Alzheimer's Disease in-vivo, and that will apply novel approaches to determine whether pathophysiology is reversible (see: http://www.buschelab.com).

The post holder will record neuronal activity and microglia dynamics using state-of-the-art two-photon imaging and/or patch-clamp electrophysiology in mouse models, and apply cutting-edge single-cell transcriptomic methods. This is an outstanding opportunity to work independently on a high impact state-of-the-art project in a stimulating vibrant research environment. The post holder will have the unique opportunity to work in close collaboration with scientists at Roche, one of the world's leading global research and development-based pharmaceutical companies, and to spend some time at their headquarters in Basel, Switzerland.

Person Criteria

Applicants must have a PhD or equivalent in Neuroscience or a neuroscience-related or quantitative discipline (eg, physics, applied mathematics, engineering, bioinformatics). Practical experience with in-vivo two-photon calcium imaging and/or patch-clamp electrophysiology, experience with live awake-behaving mice, strong programming and coding ability (eg, MATLAB, Python) and a strong analytical and/or statistical analysis background are essential. Excellent oral and written communication and inter-personal skills, proven proactive, creative and independent thinking and flexibility, the ability to meet timelines and deliverables in a collaborative environment, and a commitment to working ethically, legally and with integrity are also required.

Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (salary £31,542 - £33,257 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.

How to Apply

https://atsv7.wcn.co.uk/search_engine/jobs.cgi?amNvZGU9MTg3NDExOSZ2dF90ZW1wbGF0ZT05NjUmb3duZXI9NTA0MTE3OCZvd25lcnR5cGU9ZmFpciZicmFuZF9pZD0wJnBvc3RpbmdfY29kZT0yMjQ%3D&jcode=1874119&vt_template=965&owner=5041178&ownertype=fair&brand_id=0&posting_code=224

Contact Details

Miss E Bertram, HR Manager, UCL Queen Square Institute of Neurology (email: IoN.HRAdmin@ucl.ac.uk).