The Hong Laboratory, based in the UK DRI at UCL, investigates glia-immune mechanisms of synapse loss in age-related neurodegenerative diseases, including Alzheimer’s and Parkinson’s. We study how the brain’s immune system (microglia and border-associated macrophages) interacts with glia (astrocytes) to influence neuronal synapses, as well as peripheral immune contributions such as gut-brain signaling. Our interdisciplinary work uses cutting-edge techniques including single-cell and spatial trans
