We have developed a novel dual-guide gene therapy approach utilizing AAV9-mediated expression of CRISPR/Cas13d to suppress levels of C9orf72 sense and antisense repeat-derived transcripts (Kempthorne et al Nature Communications 2025 Jan 8;16(1):459. doi: 10.1038/s41467-024-55550-x).
This role supports an ARUK Pilot project on plasmalogen lipid depletion in iPSC-derived neurons, investigating synaptic dysfunction and testing therapeutic precursors. You will use neuronal culture, astrocyte co-cultures, gene editing, lipidomics, ICC/IF, confocal imaging, and electrophysiology.
This is an exciting opportunity to join a highly inter-disciplinary research project based at UCL Centre for Advanced Biomedical Imaging (Prof Lythgoe) and the UCL Cancer Institute (Prof Pule) to develop the next generation of cancer imaging tools and immunotherapy.
University College London, CABI, UCL Division of Medicine, London
The Neurobehavior Lab (led by Mehran Ahmadlou) in the Department of Physiology, Anatomy & Genetics at the University of Oxford, is seeking a highly motivated postdoctoral fellow to join an exciting research program.
University of Oxford, Sherrington Building, Parks Road, Oxford
